Neutropenia

 

Common causes include:

• Infection

Eg. Sepsis, salmonella, Brucella

Epstein Barr, CMV, influenza

HIV testing should be offered for any unexplained neutropenia

• Drug induced

Eg. Antithyroid medications, macrolides, procainamides, clozapine, sulphasalazine

• Autoimmune disease and Chronic Inflammatory Disease

Eg. Rheumatoid, Sjogren’s

• Nutritional deficiency

Eg. folate, B12, copper

• Bone marrow pathology

Eg. Leukaemia, myelodysplasia, lymphoma, aplastic anaemia

 

Rarer causes include congenital.

The normal range is lower for those of African ethnic descent.

 

Management:

 

                               

 

Useful reference article: https://bestpractice.bmj.com/topics/en-gb/893

 

Contributors:

Dr Richard Noble, Consultant Haematologist, RCHT

Dr Bridgitte Wesson, GP & Kernow RMS Haematology guideline lead

 

Review date: 05/08/2020

Next Review 05/08/2021