Myasthenia Gravis

 

Myasthenia gravis is an acquired autoimmune disorder characterised by fatigable weakness, typically of the periocular, facial, bulbar, and girdle muscles.

Immune disorders associated with myasthenia gravis:

• rheumatoid arthritis
• hyperthyroidism
• hypothyroidism
• polymyositis
• systemic lupus erythematosus
• pernicious anaemia
• pemphigus
• Sjogren's syndrome

Diagnosis usually confirmed by detection of Acetyl Choline receptor antibodies (90% in generalised 50% in ocular)

Tensilon tests are rarely used because of cardiac risks.

Electromyography testing for the classical decrement on repetitive stimulation is reserved for antibody negative or emergency diagnosis.

Referral: Neurology if suspect.