Myasthenia Gravis


Myasthenia gravis is an acquired autoimmune disorder characterised by fatigable weakness, typically of the periocular, facial, bulbar, and girdle muscles.

Immune disorders associated with myasthenia gravis:

  • rheumatoid arthritis
  • hyperthyroidism
  • hypothyroidism
  • polymyositis
  • systemic lupus erythematosus
  • pernicious anaemia
  • pemphigus
  • Sjogren's syndrome

Diagnosis usually confirmed by detection of Acetyl Choline receptor antibodies (90% in generalised 50% in ocular)

Tensilon tests are rarely used because of cardiac risks.

Electromyography testing for the classical decrement on repetitive stimulation is reserved for antibody negative or emergency diagnosis.

Referral: Neurology if suspect.